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Originalarbeiten 38. Hoffmann M, Honnen S, Mayatepek E, Wätjen W, Koopman WJ, Bossinger O, Distelmaier F. MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans. Exp Gerontol. 47(3):270-5 2012 37.
Huber W, Böhler P, Wätjen W, Frank W, Spingler B, Kunz PC. Cytotoxicity of
ruthenium(II) piano-stoolcomplexes withimidazole-based
PN ligands. Journal
of Organometallic Chemistry,
717,
187–194
2012 36. Wetzel C,
Kunz PC, Kassack MU, Hamacher A, Böhler P, Wätjen W,
Ott I, Rubbiani R, Spingler B: Gold(I) complexes of
water-soluble diphos-type ligands: Synthesis, anticancer activity,
apoptosis and thioredoxin reductase inhibition. angenommen bei: Dalton
Transactions 40(36):9212-20
2011
35. Noffke
AL, Bongartz M, Wätjen W, Böhler P, Spingler B, Kunz PC. Synthesis,
X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium
arene complex.
Journal
of Organometallic Chemistry, 696
(5), 1096–1101. 2011 34. Chovolou Y, Ebada SS, Wätjen W,
Proksch P. Identification of angular Naphtopyrones from the
Philippine echinoderm Comanthus species as inhibitors of the NF-kappa B
signalling pathway. Eur. J. Pharmacology, 657,
26-34, 2011 33. Brückmann NE, Wahl, M, Reiss GJ, Kohns M, Wätjen W, Kunz PC. Polymer Conjugates of Photoinducible CO Releasing Molecules. Eur. J. Inorg. Chem. 2011, 29, 4571-4577 32. Lüpertz R, Wätjen W, Kahl R, Chovolou Y. Dose- and
time-dependent effects of doxorubicin on cytotoxicity, cell cycle and
apoptotic cell death in human colon carcinoma cells. Toxicology 271,
115-121, 2010
31. Shi C, Xu M, Bayer M, Deng Z,
Wätjen W, Proksch P, Lin W. Phenolic compounds and
their protein kinase inhibition and antioxidation from Chinese Mangrove
Plant Languncularia racemosa. Phytochemistry.
71, 435-42, 2010
30. Wätjen W, Putz, A, Chovolou Y,
Kampkötter A, Totzke F,
Kubbutat MHG, Proksch P, Konuglukil B. Hexa-, Hepta- and
Nonaprenylhydroquinone isolated from Marine Sponges Sarcotragus
muscarum and Ircinia fasciculata inhibit NF-kB signalling in H4IIE
cells. Journal of Pharmacy and
Pharmacology, 61, 919-924, 2009
29. Wätjen W, Debbab A, Hohlfeld A,
Chovolou C, Kampkötter A, Edrada RA, Ebel R,
Hakiki A, Mosaddak M, Totzke F, Kubbutat MHG, Proksch P.
Enniatins A1, B and B1
from an endophytic strain of Fusarium
tricinctum induce apoptotic cell death in H4IIE hepatoma cells
accompanied by inhibition of ERK phosphorylation, Molecular Nutrition and Food Research, 53, 431-440, 2009 28. Kampkötter A, Chovolou C, Kulawik A,
Röhrdanz E, Weber N, Proksch P, Wätjen W. Isoflavone
daidzein possess no antioxidant activities in cell free assays, but
induces the antioxidant enzyme catalase. Nutrition Research, 28,
620-628, 2008 27. Lüpertz R, Chovolou Y, Unfried K, Kampkötter A, Wätjen W,
Kahl R. The forkhead transcription factor FOXO4 sensitizes cancer
cells to doxorubicin mediated cytotoxicity. Carcinogenesis, 29,
2045-2052, 2008
26. Wätjen W, Suckow-Schnitker AK,
Rohrig R, Kulawik A, Addae-Kyereme J, Wright CW,
Passreiter CM. Addisoniaflavanon III: A pro-apoptotic compound
isolated from the bark of Erythrina addisoniae. Journal of Natural
Products, 71, 735-738,
2008 25. Kampkötter A, Timpel C,
Zurawski R, Ruhl S, Chovolou Y, Proksch P, Wätjen W. Increase
of stress resistance and lifespan of Caenorhabditis elegans by
quercetin. Comp Biochem Physiol B Biochem Mol Biol. 149, 314-323, 2008
24. Lüpertz R, Chovolou Y, Kampkötter A,
Wätjen W, Kahl R. Catalase overexpression impairs
TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against
TNF-alpha. J Cell Biochem., 103(5):1497-511,
2008 23. Kampkötter A, Wiegand C,
Timpel C, Röhrdanz E, Chovolou C, Kahl R, Wätjen W.
Increased expression of catalase in human hepatoma cells by the soy
isoflavone, daidzein. Basic & Clinical Pharmacology &
Toxicology, 102, 437-442,
2008 22. Wätjen W, Kulawik A,
Suckow-Schnitker AK, Rohrig R, Ruhl R, Chovolou C,
Kampkötter A, Addae-Kyereme J, Wright CW, Passreiter CM*. Pterocarpans phaseollin
and neorautenol isolated from Erythrina addisoniae induce apoptotic
cell death accompoined by inhibition of ERK phosphorylation. Toxicology,
242(1-3):71-79,
2007 21. Kampkötter A, Nkwonkam CG, Zurawski RF,
Timpel C, Chovolou Y, Wätjen W, Kahl R.
Effects of the flavonoids kaempferol and fisetin on thermotolerance,
oxidative stress and FoxO transcription factor DAF-16 in the model
organism Caenorhabditis elegans. Archives of Toxicology, 81,
849-858, 2007 20. Wätjen W, Weber N, Lou Y-j,
Wang Z-q, Chovolou Y, Kampkötter A, Proksch P,
Kahl R. Prenylation enhances cytotoxicity of apigenin and
liquiritigenin in rat H4IIE hepatoma and C6 glioma cells. Food and
Chemical Toxicology, 45, 119-124, 2007
19. Kampkötter A, Pielarski T, Rohrig R,
Timpel C, Chovolou Y, Wätjen W, Kahl R. The
Ginkgo biloba extract Egb761 reduces stress sensitivity, ROS accumulation
and expression of catalase and glutathione S-transferase 4 in
Caenorhabditis elegans. Pharmacological Research, 55, 139-147, 2007
18. Chovolou Y, Wätjen W, Kampkötter A,
Kahl R. Downregulation of NF-kappaB activation in a H4IIE
transfectant insensitive to doxorubicin-induced apoptosis. Toxicology, 232,
89-98, 2007 17. Kampkötter A, Nkwonkam CG, Zurawski RF,
Timpel C, Chovolou Y, Wätjen W, Kahl R.
Investigations of protective effects of the flavonoids quercetin and rutin
on stress resistance in the model organism Caenorhabditis elegans. Toxicology,
234, 113-123, 2007
16. Ashour M, Edrada R, Ebel R,
Wray V, Wätjen W, Padmakumar K, Müller WEG,
Lin WH, Proksch P. New Kahalalide Derivatives from the Indian
Sacoglossan Mollusc Elysia grandifolia. Journal of Natural Products, 69,
1547-1553, 2006
15. Michels G, Wätjen W, Weber N.,
Niering P, Chovolou Y, Kampkötter A, Proksch P,
Kahl R. Resveratrol induces apoptotic cell death in rat H4IIE
hepatoma cells but necrosis in C6 glioma cells. Toxicology, 225,
173-182, 2006 14. Michels G, Mohamed G, Weber N,
Chovolou Y, Kampkötter A, Wätjen W, Proksch P.
Effects of methylated derivates of luteolin isolated from Cyperus
alopecuroides in rat H4IIE hepatoma cells. Basic & Clinical
Pharmacology & Toxicology, 98, 168-172, 2006 13. Niering P,
Michels G, Wätjen W, Ohler S, Steffan B,
Chovolou Y, Kampkötter A, Proksch P, Kahl R.
Protective and detrimental effects of kaempferol in rat H4IIE cells:
Implication of oxidative stress and apoptosis. Toxicology and Applied Pharmacology, 209, 114-122, 2005
12. Michels G, Wätjen W, Niering P,
Steffan B, Tran-Thi Q-H. Chovolou Y, Kampkötter A,
Bast A, Proksch P, Kahl R. Pro-apoptotic effects of the
flavonoid luteolin in rat H4IIE cells. Toxicology, 206, 337-348, 2005 11. Steffan B, Wätjen W,
Michels G, Niering P, Wray V, Ebel R, Edrada-Ebel R,
Kahl R, Proksch P. Polyphenols
from plants used in traditional Indonesian medicine (Jamu) - uptake and
antioxidative effects in rat H4IIE hepatoma cells. Journal of Pharmacy
and Pharmacology, 57, 233-240, 2005
10. Wätjen W, Michels G, Steffan B,
Niering P, Chovolou Y, Kampkötter A, Tran-Thi Q-H,
Proksch P, Kahl R. Low concentrations of flavonoids are
protective in rat H4IIE cells whereas high concentrations cause DNA damage
and apoptosis. Journal of Nutrition,
135, 525-531, 2005
9. Di Virgilio AL, Iwami K, Wätjen W,
Kahl R, Degen GH. Genotoxicity of the isoflavones genistein,
daidzein and equol in V79 cells. Toxicology Letters, 151, 151-162, 2004
8. Wätjen W, Beyersmann D.
Cadmium induces apoptosis in C6 glioma cells: influence of oxidative
stress. Biometals, 17, 65-78, 2004
7. Michels G, Haenen GR, Wätjen W,
Rietjens S, Bast A. The thiol reactivity of the oxidation
product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids. Toxicology Letters, 151,
105-111, 2004 6. Chovolou Y, Wätjen W, Kampkötter A,
Kahl R. Resistance to TNF-a induced apoptosis in
rat hepatoma cells expressing TNF-a is linked to low
antioxidant expression. Journal of
Biological Chemistry, 278,
29626-29632, 2003
5. Wätjen W, Biagioli M, Cox M,
Beyersmann D. Cadmium induces apoptosis in C6 glioma cells mediated
by caspase 9-activation. Biometals,
15, 15-25, 2002 4. Wätjen W, Haase H, Biagioli M,
Beyersmann D. Induction of apoptosis in mammalian cells by
cadmium and zinc. Environmental
Health Perspectives,
110 (Suppl. 5), 865-867, 2002
3. Biagioli M, Wätjen W,
Beyersmann D, Zoncu R, Cappellini C, Ragghianti M,
Cremisi F, Bucci S. Cadmium induced apoptosis in murine
fibroblasts is suppressed by Bcl-2. Archives of Toxicology, 75,
313-320, 2001 2. Haase H, Wätjen W, Beyersmann D.
Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat
glioma cells. Biological Chemistry, 382, 1227-1234, 2001
1. Wätjen W, Benters J, Haase H,
Schwede F, Jastorff B, Beyersmann D. Zn2+ and Cd2+
increase the cyclic GMP level in PC12 cells by inhibition of the cyclic
nucleotide phosphodiesterase. Toxicology, 157, 167-175, 2001
Übersichtsartikel 4.. Wätjen W,
Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und
Toxikologie: Teil 2: Phase-II-Reaktionen, Apotheken-Magazin
9, 6-13, 2010 3. Wätjen W,
Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und
Toxikologie: Teil 1: Phase-I-Reaktionen, Apotheken-Magazin
5, 8-14, 2009 2. Passreiter
C, Wätjen W. Hexenkräuter,
Hexenmedizin. Apotheken-Magazin
5, 8-14, 2007 1. Kahl R,
Kampkötter A, Wätjen W, Chovolou Y. Antioxidant
enzymes and apoptosis. Drug Metabolism Reviews, 36, 747-762,
2004
eingereichte
Arbeiten Hamed ANES, Wätjen
W, Schmitz R, Chovolou Y, Edrada-Ebel RA, Youssef DTA, Salah Kamel M,
Proksch P. A New Bioactive
Sesquiterpenoid Quinone from the Mediterranean Sea Marine Sponge Dysidea
avara eingereicht bei: “Natural Product Communications“ Havermann
S, Rohrig R, Chovolou Y, Humpf HU, Wätjen W. Molecular Effects of Baicalein in Hct116 Cells and Caenorhabditis
elegans: Activation of the Nrf2 Signalling Pathway and Prolongation of
Lifespan.eingereicht bei: “Journal of Agricultural and Food Chemistry”
Bücher/Buchbeiträge 10. Kahl R, Wätjen
W. Morphologie und Funktion der Leber. In: Marquardt H, Schäfer SG
und Barth H (Herausgeber) Toxikologie, 3. Auflage, Erscheinungstermin: 2013 9. Wätjen W,
Fritsche E. Fremdstoff-Metabolismus. In: HW Vohr (Herausgeber): Toxikologie
(Band I: Grundlagen der Toxikologie), Wiley-VCH-Verlag ISBN:
978-3527-32319-7, 2010 8. Wätjen W,
Chovolou Y, Bolt HM, Toxikologie von Gasen. In: HW Vohr
(Herausgeber): Toxikologie (Band II:
Toxikologie der Stoffe), Wiley-VCH-Verlag ISBN: 978-3527-32385-2, 2010 7. Kahl R, Wätjen W. Liver injury
in man ascribed to non-drug chemicals and natural toxins. In: Textbook
of Hepatology: From Basic Science to Clinical Practice (Editors:
Rodes, Benhamou, Blei, Reichen, Rizzetto), Blackwell Publishing; 3rd
edition, ISBN: 978-1-4051-2741-7, page 2105-2121, 2007 6. Wätjen W,
Chovolou Y, Kampkötter A, Kahl R. Antiapoptotic and
proapoptotic effects of polyphenols. In: New Cell Apoptosis Research
(Editor: L.C. Vinter), Nova Science Publishers, Inc. N.Y. ISBN:
1-60021-430-4, 2006 5. Wätjen W,
Chovolou Y, Kampkötter A, Kahl R. Anti- and prooxidative effects of flavonoids, in: Leading
Edge Antioxidant Research (Editor: H.V. Panglossi), Nova
Science Publishers, Inc. N.Y. ISBN: 1-60021-274-3, 2006 4. Wätjen W, Chovolou Y, Niering P,
Kampkötter A, Tran-Thi Q-H, Kahl R. Pro- and antiapoptotic
effects of flavonoids in H4IIE cells: implication of oxidative stress. DFG-Symposium
“Functional Food: Safety Aspects”, Senate Commission on Food Safety, VCH-Wiley, 338-344,
2004 3. Kampkötter A, Röhrdanz E, Iwami K,
Ohler S, Wätjen W, Chovolou Y, Kulling S, Kahl R.
Influence of daidzein and its metabolites on the expression of catalase in
rat hepatoma cells. DFG-Symposium “Functional Food: Safety Aspects”, Senate.
Commission on Food Safety, VCH-Wiley, 293-298, 2004 2. Niering P, Wätjen W, Ohler S,
Köhler I, Chovolou Y, Kampkötter A, Tran-Thi Q-H,
Kahl R. Investigation of Oxidative Stress in H4IIE Cells: Modulation
by the Flavonoid Kaempferol. DFG-Symposium “Functional Food: Safety Aspects”, Senate Commission
on Food Safety, VCH-Wiley,
319-325, 2004 1. Wätjen W. Cadmium-induzierte Apoptose in Säugerzellen:
Einfluss von intrazellulärer Signaltransduktion und oxidativem Stress. GCA-Verlag;
ISBN 3-89863-064-1, 2001
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